学歴および職歴
1989年 東京大学医学部医学科卒業
1989年 東京大学医学部附属病院内科 医員（研修医）
1990年 東京大学大学院医学系研究科博士課程入学
1992年 東京大学大学院医学系研究科博士課程中退
1992年 寄付講座教員 東京大学薬学部 機能病態学教室 助手相当
1995年 文部教官 東京大学医学部附属脳研究施設 脳解剖学教室 助手
1996年 文部教官 東京大学医学部附属脳研究施設 脳解剖学教室 講師
1997年 文部教官 東京大学大学院医学系研究科 細胞生物学解剖学大講座 講師
2001年 文部科学教官 群馬大学生体調節研究所 細胞構造分野 教授
2004年 国立大学法人 群馬大学生体調節研究所 細胞構造分野 教授
2009年 国立大学法人 大阪大学大学院医学系研究科 細胞生物学 教授
現在に至る
教育歴
1992年～2001年 東京大学医学部医学科にて組織学および肉眼解剖学の実習を担当
2001年～2009年 群馬大学医学部医学科の非常勤講師として組織学および肉眼解剖学の講義・実習を担当
2003年～2009年 群馬大学医学部保健学科の非常勤講師として生物学講義を担当
2009年～現在 大阪大学大学院医学系研究科教授として組織学の講義・実習を担当
学会活動
日本解剖学会会員（評議員）、日本細胞生物学会会員（評議員）、
日本分子生物学会会員、日本神経科学会会員、アメリカ細胞生物学会会員
原著論文
Kawamura N, Wada S, Aoyama M, Harada A, Takasuga S, Sasaki T, Wada Y.
Delivery of Endosomes to Lysosomes via Microautophagy in the Visceral Endoderm of Mouse Embryos.
Nature Communications, in press, (2012).
Hashimoto Y, Muramatsu K, Kunii M, Yoshimura S, Yamada M, Sato T, Ishida Y, Harada R, Harada A. (The first two authors contributed equally to this paper).
Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector.
FASEB Journal, doi: 10.1096/fj.12-207530, (2012).
Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F.
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Endocrinology, 153: 4171-4180; doi:10.1210/en.2012-1164, (2012).
Sakamori R, Das S, Yu S, Feng S, Stypulkowski E, Guan Y, Douard V, Tang W, Ferraris RP, Harada A, Brakebusch C, Guo W, Gao N.
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Journal of Clinical Investigation, 122: 1052-1065; doi: 10.1172/JCI60282, (2012).
Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Sato K, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A.
The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo.
Traffic, 12: 1383-1393; doi: 10.1111/j.1600-0854.2011.01247.x, (2011).
Sato M, Saegusa K, Sato K, Hara T, Harada A, Sato K.
Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells.
Molecular Biology of the Cell, 22: 2579-2587; doi: 10.1091/mbc.E11-04-0279, (2011).
Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, Mori K.
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress.
Molecular Biology of the Cell, 21: 2975-2986; doi: 10.1091/mbc.E09-02-0133, (2010).
Harada A.
Molecular mechanism of polarized transport.
Journal of Biochemistry, 147: 619-624; doi: 10.1093/jb/mvq027, (2010).
Akiyama H, Gotoh A, Shin RW, Koga T, Ohashi T, Sakamoto W, Harada A, Arai H, Sawa A, Uchida C, Uchida T.
A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.
Journal of Biological Chemistry, 284: 32695-32699; doi: 10.1074/jbc.M109.035998, (2009).
Tanaka S, Kunii M, Harada A, Okabe S.
Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts.
Genesis, 47: 638-646; doi: 10.1002/dvg.20544, (2009).
Uemura T, Sato T, Aoki T, Yamamoto A, Okada T, Hirai R, Harada R, Mori K, Tagaya M, Harada A.
p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.
Molecular and Cellular Biology, 29: 1869-1881; doi: 10.1128/MCB.01089-08, (2009).
Kato Y, Sugiura T, Nakadera Y, Sugiura M, Kubo Y, Sato T, Harada A, Tsuji A.
Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice.
Drug Metabolism and Disposition, 37: 602-607; doi: 10.1124/dmd.108.023689, (2009).
Sadakata H, Okazawa H, Sato T, Supriatna Y, Ohnishi H, Kusakari S, Murata Y, Ito T, Nishiyama U, Minegishi T, Harada A, Matozaki T.
SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.
Genes to Cells, 14: 295-308; doi: 10.1111/j.1365-2443.2008.01270.x, (2009).
Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F.
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.
Journal of Immunology, 182: 3243-3251; doi: 10.4049/jimmunol.0803466, (2009).
Sato M, Grant BD, Harada A, Sato K.
Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans.
Journal of Cell Science, 121: 3177-3186; doi: 10.1242/jcs.034678, (2008).
Muramatsu K, Hashimoto Y, Uemura T, Kunii M, Harada R, Sato T, Morikawa A, Harada A.
Neuron-specific recombination by Cre recombinase inserted into the murine tau locus.
Biochemical and Biophysical Research Communications, 370: 419-423; doi: 10.1016/j.bbrc.2008.03.103, (2008).
Sato M, Sato K, Liou W, Pant S, Harada A, Grant BD.
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.
EMBO Journal, 27: 1183-1196; doi: 10.1038/emboj.2008.54, (2008).
Hashimoto Y, Muramatsu K, Uemura T, Harada R, Sato T, Okamoto K, Harada A.
Neuron-specific and inducible recombination by Cre recombinase in the mouse.
Neuroreport, 19: 621-624, (2008).
Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K.
ATF6 is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum.
Cell Structure and Function, 33: 75-89; doi: 10.1247/csf.07044, (2008).
Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A.
The Rab8 GTPase regulates apical protein localization in intestinal cells.
Nature, 448: 366-369; doi: 10.1038/nature05929, (2007).
Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A, Mori K. (The first two authors contributed equally to this paper).
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
Developmental Cell, 13: 365-376, (2007).
Fujio K, Sato M, Uemura T, Sato T, Sato-Harada R, Harada A.
14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice.
Neuroreport, 18: 1049-1052, (2007).
Hou X, Wei L, Harada A, Tatamoto K.
Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.
Lung Cancer, 54: 143-148, (2006).
Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, Uchida S.
Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation.
Proc Natl Acad Sci USA, 103: 14217-14222, (2006).
Iriuchijima N, Sato-Harada R, Takano M, Fujio K, Sato T, Goto F, Harada A.
Reduced expression of kinase-associated phosphatase in cortical dendrites of MAP2-deficient mice.
Biochemical and Biophysical Research Communications, 338: 1216-1221, (2005).
Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, Komachi M, Malchinkhuu E, Murata N, Kimura T, Kuwabara A, Wakamatsu K, Koizumi H, Uede T, Tsujimoto G, Kurose H, Sato T, Harada A, Misawa N, Tomura H, Okajima F.
TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor.
Journal of Biological Chemistry, 279: 45626-45633, (2004).
Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, Zhu G, Kasagi Y, Kamiya H, Harada A, Nishimura K, Takeuchi A, Miyazaki T, Watanabe M, Yuasa S, Manabe T, Wakabayashi K, Kaneko S, Saito S, Ohno H.
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor.
Journal of Cell Biology, 167: 293-302, (2004).
Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y.
Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau.
Journal of Biological Chemistry, 279: 27272-27277, (2004).
Hayashi K, Kawai-Hirai R, Harada A, Takata K.
Inhibitory neurons from fetal rat cerebral cortex exert delayed axon formation and active migration in vitro.
Journal of Cell Science, 116: 4419-4428, (2003).
Harada A, Teng J, Takei Y, Oguchi K, Hirokawa N.
MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction.
Journal of Cell Biology, 158: 541-549, (2002).
Sato T, Sato-Harada R, Takano M, Kato S, Saburi S, and Harada A.
Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neurons.
Neuroscience Letters, 325: 83-86, (2002).
Teng J, Takei Y, Harada A, Nakata T, Chen J, Hirokawa N.
Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization.
J Cell Biol, 155: 65-76, (2001).
Takei Y, Teng J, Harada A, Hirokawa N.
Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes.
Journal of Cell Biology, 150: 989-1000, (2000).
Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S, Hirokawa N.
KIF5C, a novel neuronal kinesin enriched in motor neurons.
Journal of Neuroscience, 20: 6374-6384, (2000).
Ikegami S, Harada A, Hirokawa, N. (The first two authors contributed equally to this paper).
Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.
Neuroscience Letters, 279: 129-132, (2000).
Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N.
Randomization of Left-Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein.
Cell, 95: 829-837, (1998).
Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N.
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.
Cell, 93: 1147-1158, (1998).
Yonekawa Y, Harada A, Okada Y, Funakoshi T, Kanai Y, Takei Y, Terada S, Noda T, Hirokawa N.
Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice.
J Cell Biol, 141: 431-441, (1998).
Harada A, Takei Y, Kanai Y, Tanaka Y, Nonaka S, Hirokawa N.
Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein.
Journal of Cell Biology, 141: 51-59, (1998).
Takei Y, Kondo S, Harada A, Inomata S, Noda T, Hirokawa N.
Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene.
Journal of Cell Biology, 137: 1615-1626, (1997).
Takei Y, Harada A, Takeda S, Kobayashi K, Terada S, Noda T, Takahashi T, Hirokawa N.
Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system.
Journal of Cell Biology, 131: 1789-1800, (1995).
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, Takei Y, Noda T, Hirokawa N.
Altered microtubule organization in small-calibre axons of mice lacking tau protein.
Nature, 369: 488-491, (1994).
Harada A, Sobue K, Hirokawa N.
Developmental changes of synapsin I subcellular localization in rat cerebellar neurons.
Cell Structure and Function, 15: 329-342, (1990).
Hirokawa N, Sobue K, Kanda K, Harada A, Yorifuji H.
The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin1.
Journal of Cell Biology, 108: 111-126, (1989).
著作
人体の構造と機能および疾病の成り立ち 人体の構造と生理機能 (単行本)
原田玲子・原田彰宏・小林直人 編著、医歯薬出版 (2007).